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|00000470| 24 44 61 74 65 7b 53 65 | 70 74 65 6d 62 65 72 20 |$Date{Se|ptember |
|00000480| 31 39 38 37 7d 0d 0a 24 | 59 42 56 6f 6c 7b 31 39 |1987}..$|YBVol{19|
|00000490| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
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|000004b0| 43 68 61 70 74 65 72 7b | 31 2d 31 7d 0d 0a 24 59 |Chapter{|1-1}..$Y|
|000004c0| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 48 6f 6c |BEditor{|Drs. Hol|
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|000004f0| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 4c 2e 20 4c |Commenta|tor{L. L|
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|00000520| 65 61 72 20 42 6f 6f 6b | 20 4d 65 64 69 63 61 6c |ear Book| Medical|
|00000530| 20 50 75 62 6c 69 73 68 | 65 72 73 2c 20 49 6e 63 | Publish|ers, Inc|
|00000540| 2e 2c 20 31 39 38 39 0d | 0a 0d 0a 31 39 38 39 20 |., 1989.|...1989 |
|00000550| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 44 72 75 |Year Boo|k of Dru|
|00000560| 67 20 54 68 65 72 61 70 | 79 20 28 52 29 0d 0a 0d |g Therap|y (R)...|
|00000570| 0a 43 68 61 70 74 65 72 | 20 31 2d 2d 47 65 6e 65 |.Chapter| 1--Gene|
|00000580| 72 61 6c 20 49 6e 66 6f | 72 6d 61 74 69 6f 6e 0d |ral Info|rmation.|
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|000005e0| 2d 2d 2d 0d 0a 54 68 65 | 20 43 6f 6e 73 65 6e 74 |---..The| Consent|
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|00002900| 2d 0d 0a 54 68 65 20 46 | 44 41 20 41 64 76 69 73 |-..The F|DA Advis|
|00002910| 6f 72 79 20 50 61 6e 65 | 6c 27 73 20 44 65 63 69 |ory Pane|l's Deci|
|00002920| 73 69 6f 6e 20 6f 6e 20 | 72 74 2d 50 41 0d 0a 0d |sion on |rt-PA...|
|00002930| 0a 53 68 65 72 72 79 20 | 53 0d 0a 28 54 65 6d 70 |.Sherry |S..(Temp|
|00002940| 6c 65 20 55 6e 69 76 2c | 20 50 68 69 6c 61 64 65 |le Univ,| Philade|
|00002950| 6c 70 68 69 61 29 0d 0a | 4a 20 43 6c 69 6e 20 50 |lphia)..|J Clin P|
|00002960| 68 61 72 6d 61 63 6f 6c | 20 32 37 3a 37 33 30 2d |harmacol| 27:730-|
|00002970| 37 33 34 2c 20 4f 63 74 | 6f 62 65 72 20 31 39 38 |734, Oct|ober 198|
|00002980| 37 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |7..-----|--------|
|00002990| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|000029b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029d0| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|000029e0| 0a 0d 0a 20 20 20 20 20 | 54 68 65 20 62 65 6e 65 |...     |The bene|
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|00002a30| 0a 74 68 72 6f 6d 62 6f | 6c 79 74 69 63 20 61 67 |.thrombo|lytic ag|
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|00002a70| 20 54 68 65 72 65 66 6f | 72 65 2c 20 61 6e 0d 0a | Therefo|re, an..|
|00002a80| 61 64 76 69 73 6f 72 79 | 20 70 61 6e 65 6c 27 73 |advisory| panel's|
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|00002c00| 6f 6d 6d 65 6e 64 61 74 | 69 6f 6e 20 74 6f 20 62 |ommendat|ion to b|
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|00002db0| 62 6f 6c 79 74 69 63 20 | 74 68 65 72 61 70 79 2e |bolytic |therapy.|
|00002dc0| 20 20 49 6e 20 61 64 64 | 69 74 69 6f 6e 2c 20 72 |  In add|ition, r|
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|00002df0| 70 74 6f 6b 69 6e 61 73 | 65 2e 0d 0a 20 20 20 20 |ptokinas|e...    |
|00002e00| 20 42 65 63 61 75 73 65 | 20 74 68 65 72 65 20 77 | Because| there w|
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|00002e20| 20 62 61 73 69 73 20 66 | 6f 72 20 73 70 65 63 69 | basis f|or speci|
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|00002e40| 6f 6e 73 20 6f 66 20 74 | 68 65 0d 0a 66 6f 72 6d |ons of t|he..form|
|00002e50| 2c 20 64 6f 73 65 2c 20 | 64 75 72 61 74 69 6f 6e |, dose, |duration|
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|00002e70| 72 74 2d 50 41 2c 20 61 | 6e 64 20 62 65 63 61 75 |rt-PA, a|nd becau|
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|00002e90| 20 68 61 73 20 62 65 65 | 6e 0d 0a 73 68 6f 77 6e | has bee|n..shown|
|00002ea0| 20 74 6f 20 72 65 64 75 | 63 65 20 6d 6f 72 74 61 | to redu|ce morta|
|00002eb0| 6c 69 74 79 2c 20 74 68 | 65 72 65 20 77 61 73 20 |lity, th|ere was |
|00002ec0| 6a 75 73 74 69 66 69 63 | 61 74 69 6f 6e 20 66 6f |justific|ation fo|
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|00002ee0| 61 6e 65 6c 27 73 0d 0a | 64 65 63 69 73 69 6f 6e |anel's..|decision|
|00002ef0| 20 74 6f 20 72 65 63 6f | 6d 6d 65 6e 64 20 64 65 | to reco|mmend de|
|00002f00| 6c 61 79 20 69 6e 20 74 | 68 65 20 61 70 70 72 6f |lay in t|he appro|
|00002f10| 76 61 6c 20 6f 66 20 72 | 74 2d 50 41 20 66 6f 72 |val of r|t-PA for|
|00002f20| 20 74 68 65 20 74 72 65 | 61 74 6d 65 6e 74 20 6f | the tre|atment o|
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|00002f50| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
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|000030d0| 4c 2e 20 4c 61 73 61 67 | 6e 61 2c 20 4d 2e 44 2e |L. Lasag|na, M.D.|
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|00003130| 0a 76 61 6e 20 5a 77 61 | 6e 65 6e 62 65 72 67 2c |.van Zwa|nenberg,|
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|00003150| 47 72 65 67 6f 72 79 2c | 20 44 41 7d 0d 0a 24 41 |Gregory,| DA}..$A|
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|00003220| 0a 24 44 61 74 65 7b 4a | 75 6c 79 20 31 39 38 37 |.$Date{J|uly 1987|
|00003230| 7d 0d 0a 24 59 42 56 6f | 6c 7b 31 39 38 39 20 59 |}..$YBVo|l{1989 Y|
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|000032f0| 39 38 39 0d 0a 0d 0a 31 | 39 38 39 20 59 65 61 72 |989....1|989 Year|
|00003300| 20 42 6f 6f 6b 20 6f 66 | 20 44 72 75 67 20 54 68 | Book of| Drug Th|
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|00003390| 0a 43 61 6e 20 52 61 74 | 69 6f 6e 61 6c 20 50 72 |.Can Rat|ional Pr|
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|00003400| 20 45 6e 67 6c 61 6e 64 | 29 0d 0a 4a 20 52 20 43 | England|)..J R C|
|00003410| 6f 6c 6c 20 47 65 6e 20 | 50 72 61 63 74 20 33 37 |oll Gen |Pract 37|
|00003420| 3a 33 30 38 2d 33 31 30 | 2c 20 4a 75 6c 79 20 31 |:308-310|, July 1|
|00003430| 39 38 37 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |987..---|--------|
|00003440| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003480| 2d 2d 2d 2d 2d 0d 0a 0d | 0a 41 62 73 74 72 61 63 |-----...|.Abstrac|
|00003490| 74 0d 0a 0d 0a 20 20 20 | 20 20 47 65 6e 65 72 61 |t....   |  Genera|
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|000034b0| 28 47 50 73 29 20 6d 61 | 79 20 70 72 65 73 63 72 |(GPs) ma|y prescr|
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|00003590| 54 68 65 20 70 72 65 73 | 63 72 69 62 69 6e 67 20 |The pres|cribing |
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|000035e0| 74 68 65 79 20 70 61 72 | 74 69 63 69 70 61 74 65 |they par|ticipate|
|000035f0| 64 20 69 6e 20 61 6e 20 | 65 64 75 63 61 74 69 6f |d in an |educatio|
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|00003d50| 48 6f 6c 6c 69 73 74 65 | 72 2c 20 4d 2e 44 2e 7d |Holliste|r, M.D.}|
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|00003d90| 49 6e 63 2e 2c 20 31 39 | 38 39 0d 0a 0d 0a 31 39 |Inc., 19|89....19|
|00003da0| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
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|00003dc0| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 31 2d 2d 47 |....Chap|ter 1--G|
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|00003e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e30| 2d 2d 2d 2d 2d 2d 0d 0a | 50 72 65 73 63 72 69 62 |------..|Prescrib|
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|00003e60| 74 61 67 68 20 4a 0d 0a | 28 4d 6f 6e 61 73 68 20 |tagh J..|(Monash |
|00003e70| 55 6e 69 76 2c 20 56 69 | 63 74 6f 72 69 61 29 0d |Univ, Vi|ctoria).|
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|00003ea0| 4a 75 6c 79 20 31 39 38 | 37 0d 0a 2d 2d 2d 2d 2d |July 198|7..-----|
|00003eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ef0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
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|00004770| 41 75 74 68 6f 72 7b 0d | 0a 53 61 75 6e 64 65 72 |Author{.|.Saunder|
|00004780| 73 2c 20 43 45 7d 0d 0a | 24 41 66 66 69 6c 69 61 |s, CE}..|$Affilia|
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|000047e0| 65 72 20 64 65 70 61 72 | 74 6d 65 6e 74 3b 0d 0a |er depar|tment;..|
|000047f0| 45 6d 65 72 67 65 6e 63 | 79 20 64 65 70 61 72 74 |Emergenc|y depart|
|00004800| 6d 65 6e 74 2c 20 64 69 | 73 63 68 61 72 67 65 20 |ment, di|scharge |
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|00004860| 72 74 6d 65 6e 74 7d 0d | 0a 24 4a 6f 75 72 6e 61 |rtment}.|.$Journa|
|00004870| 6c 7b 4a 20 45 6d 65 72 | 67 20 4d 65 64 7d 0d 0a |l{J Emer|g Med}..|
|00004880| 24 56 6f 6c 75 6d 65 7b | 35 7d 0d 0a 24 50 61 67 |$Volume{|5}..$Pag|
|00004890| 65 7b 32 38 33 2d 32 38 | 36 7d 0d 0a 24 44 61 74 |e{283-28|6}..$Dat|
|000048a0| 65 7b 4a 75 6c 79 20 31 | 39 38 37 7d 0d 0a 24 59 |e{July 1|987}..$Y|
|000048b0| 42 56 6f 6c 7b 31 39 38 | 39 20 59 65 61 72 20 42 |BVol{198|9 Year B|
|000048c0| 6f 6f 6b 20 6f 66 20 44 | 72 75 67 20 54 68 65 72 |ook of D|rug Ther|
|000048d0| 61 70 79 7d 0d 0a 24 43 | 68 61 70 74 65 72 7b 31 |apy}..$C|hapter{1|
|000048e0| 2d 37 7d 0d 0a 24 59 42 | 45 64 69 74 6f 72 7b 44 |-7}..$YB|Editor{D|
|000048f0| 72 73 2e 20 48 6f 6c 6c | 69 73 74 65 72 20 61 6e |rs. Holl|ister an|
|00004900| 64 20 4c 61 73 61 67 6e | 61 7d 0d 0a 24 54 61 62 |d Lasagn|a}..$Tab|
|00004910| 6c 65 7b 7d 0d 0a 24 43 | 6f 6d 6d 65 6e 74 61 74 |le{}..$C|ommentat|
|00004920| 6f 72 7b 4c 2e 20 4c 61 | 73 61 67 6e 61 2c 20 4d |or{L. La|sagna, M|
|00004930| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00004940| 74 20 28 63 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (c) Ye|ar Book |
|00004950| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00004960| 72 73 2c 20 49 6e 63 2e | 2c 20 31 39 38 39 0d 0a |rs, Inc.|, 1989..|
|00004970| 0d 0a 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |..1989 Y|ear Book|
|00004980| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
|00004990| 20 28 52 29 0d 0a 0d 0a | 43 68 61 70 74 65 72 20 | (R)....|Chapter |
|000049a0| 31 2d 2d 47 65 6e 65 72 | 61 6c 20 49 6e 66 6f 72 |1--Gener|al Infor|
|000049b0| 6d 61 74 69 6f 6e 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |mation..|..------|
|000049c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 50 61 74 69 |--------|--..Pati|
|00004a10| 65 6e 74 20 43 6f 6d 70 | 6c 69 61 6e 63 65 20 69 |ent Comp|liance i|
|00004a20| 6e 20 46 69 6c 6c 69 6e | 67 20 50 72 65 73 63 72 |n Fillin|g Prescr|
|00004a30| 69 70 74 69 6f 6e 73 20 | 41 66 74 65 72 20 44 69 |iptions |After Di|
|00004a40| 73 63 68 61 72 67 65 20 | 46 72 6f 6d 20 74 68 65 |scharge |From the|
|00004a50| 20 45 6d 65 72 67 65 6e | 63 79 0d 0a 44 65 70 61 | Emergen|cy..Depa|
|00004a60| 72 74 6d 65 6e 74 0d 0a | 0d 0a 53 61 75 6e 64 65 |rtment..|..Saunde|
|00004a70| 72 73 20 43 45 0d 0a 28 | 56 61 6e 64 65 72 62 69 |rs CE..(|Vanderbi|
|00004a80| 6c 74 20 55 6e 69 76 29 | 0d 0a 4a 20 45 6d 65 72 |lt Univ)|..J Emer|
|00004a90| 67 20 4d 65 64 20 35 3a | 32 38 33 2d 32 38 36 2c |g Med 5:|283-286,|
|00004aa0| 20 4a 75 6c 79 20 31 39 | 38 37 0d 0a 2d 2d 2d 2d | July 19|87..----|
|00004ab0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004ac0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004ad0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004ae0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004af0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00004b00| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|....    |
|00004b10| 20 41 6c 74 68 6f 75 67 | 68 20 70 61 74 69 65 6e | Althoug|h patien|
|00004b20| 74 20 63 6f 6d 70 6c 69 | 61 6e 63 65 20 69 6e 20 |t compli|ance in |
|00004b30| 74 61 6b 69 6e 67 20 70 | 72 65 73 63 72 69 62 65 |taking p|rescribe|
|00004b40| 64 20 6d 65 64 69 63 61 | 74 69 6f 6e 20 68 61 73 |d medica|tion has|
|00004b50| 20 62 65 65 6e 20 77 65 | 6c 6c 0d 0a 73 74 75 64 | been we|ll..stud|
|00004b60| 69 65 64 2c 20 70 61 74 | 69 65 6e 74 20 63 6f 6d |ied, pat|ient com|
|00004b70| 70 6c 69 61 6e 63 65 20 | 69 6e 20 66 69 6c 6c 69 |pliance |in filli|
|00004b80| 6e 67 20 70 72 65 73 63 | 72 69 70 74 69 6f 6e 73 |ng presc|riptions|
|00004b90| 20 68 61 73 20 72 65 63 | 65 69 76 65 64 20 6c 65 | has rec|eived le|
|00004ba0| 73 73 0d 0a 61 74 74 65 | 6e 74 69 6f 6e 2e 20 20 |ss..atte|ntion.  |
|00004bb0| 44 75 72 69 6e 67 20 61 | 20 32 2d 77 65 65 6b 20 |During a| 2-week |
|00004bc0| 73 74 75 64 79 20 70 65 | 72 69 6f 64 2c 20 34 37 |study pe|riod, 47|
|00004bd0| 20 77 6f 6d 65 6e 20 28 | 34 39 25 29 20 61 6e 64 | women (|49%) and|
|00004be0| 20 34 39 20 6d 65 6e 20 | 28 35 31 25 29 20 28 6d | 49 men |(51%) (m|
|00004bf0| 65 61 6e 0d 0a 61 67 65 | 2c 20 32 37 2e 31 20 79 |ean..age|, 27.1 y|
|00004c00| 65 61 72 73 29 20 77 68 | 6f 20 77 65 72 65 20 67 |ears) wh|o were g|
|00004c10| 69 76 65 6e 20 70 72 65 | 73 63 72 69 70 74 69 6f |iven pre|scriptio|
|00004c20| 6e 73 20 66 6f 72 20 6d | 65 64 69 63 61 74 69 6f |ns for m|edicatio|
|00004c30| 6e 20 61 74 20 64 69 73 | 63 68 61 72 67 65 20 66 |n at dis|charge f|
|00004c40| 72 6f 6d 0d 0a 74 68 65 | 20 65 6d 65 72 67 65 6e |rom..the| emergen|
|00004c50| 63 79 20 64 65 70 61 72 | 74 6d 65 6e 74 20 77 65 |cy depar|tment we|
|00004c60| 72 65 20 66 6f 6c 6c 6f | 77 65 64 20 75 70 20 77 |re follo|wed up w|
|00004c70| 69 74 68 20 61 20 74 65 | 6c 65 70 68 6f 6e 65 20 |ith a te|lephone |
|00004c80| 63 61 6c 6c 20 74 68 65 | 20 6e 65 78 74 20 64 61 |call the| next da|
|00004c90| 79 20 74 6f 0d 0a 64 65 | 74 65 72 6d 69 6e 65 20 |y to..de|termine |
|00004ca0| 63 6f 6d 70 6c 69 61 6e | 63 65 20 69 6e 20 66 69 |complian|ce in fi|
|00004cb0| 6c 6c 69 6e 67 20 74 68 | 65 69 72 20 70 72 65 73 |lling th|eir pres|
|00004cc0| 63 72 69 70 74 69 6f 6e | 73 2e 0d 0a 20 20 20 20 |cription|s...    |
|00004cd0| 20 54 65 6c 65 70 68 6f | 6e 65 20 66 6f 6c 6c 6f | Telepho|ne follo|
|00004ce0| 77 2d 75 70 20 72 65 76 | 65 61 6c 65 64 20 74 68 |w-up rev|ealed th|
|00004cf0| 61 74 20 31 31 20 28 32 | 31 25 29 20 6f 66 20 35 |at 11 (2|1%) of 5|
|00004d00| 33 20 69 6e 73 75 72 65 | 64 20 70 61 74 69 65 6e |3 insure|d patien|
|00004d10| 74 73 2c 20 34 20 28 32 | 31 25 29 0d 0a 6f 66 20 |ts, 4 (2|1%)..of |
|00004d20| 31 39 20 4d 65 64 69 63 | 61 69 64 20 70 61 74 69 |19 Medic|aid pati|
|00004d30| 65 6e 74 73 2c 20 33 20 | 28 32 31 25 29 20 6f 66 |ents, 3 |(21%) of|
|00004d40| 20 31 34 20 73 65 6c 66 | 2d 70 61 79 69 6e 67 20 | 14 self|-paying |
|00004d50| 70 61 74 69 65 6e 74 73 | 2c 20 31 20 28 32 35 25 |patients|, 1 (25%|
|00004d60| 29 20 6f 66 20 34 0d 0a | 4d 65 64 69 63 61 72 65 |) of 4..|Medicare|
|00004d70| 20 70 61 74 69 65 6e 74 | 73 2c 20 61 6e 64 20 33 | patient|s, and 3|
|00004d80| 20 28 35 30 25 29 20 70 | 61 74 69 65 6e 74 73 20 | (50%) p|atients |
|00004d90| 6f 66 20 75 6e 6b 6e 6f | 77 6e 20 70 61 79 6f 72 |of unkno|wn payor|
|00004da0| 20 73 74 61 74 75 73 20 | 68 61 64 20 6e 6f 74 20 | status |had not |
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|00004dc0| 72 20 70 72 65 73 63 72 | 69 70 74 69 6f 6e 73 2e |r prescr|iptions.|
|00004dd0| 20 20 52 65 61 73 6f 6e | 73 20 67 69 76 65 6e 20 |  Reason|s given |
|00004de0| 66 6f 72 20 6e 6f 6e 63 | 6f 6d 70 6c 69 61 6e 63 |for nonc|omplianc|
|00004df0| 65 20 69 6e 63 6c 75 64 | 65 64 0d 0a 69 6e 73 75 |e includ|ed..insu|
|00004e00| 66 66 69 63 69 65 6e 74 | 20 66 75 6e 64 73 20 28 |fficient| funds (|
|00004e10| 33 36 25 29 2c 20 6c 61 | 63 6b 20 6f 66 20 74 72 |36%), la|ck of tr|
|00004e20| 61 6e 73 70 6f 72 74 61 | 74 69 6f 6e 20 28 31 34 |ansporta|tion (14|
|00004e30| 25 29 2c 20 6e 65 67 6c | 69 67 65 6e 63 65 20 28 |%), negl|igence (|
|00004e40| 33 32 25 29 2c 20 61 6e | 64 0d 0a 6d 69 73 63 65 |32%), an|d..misce|
|00004e50| 6c 6c 61 6e 65 6f 75 73 | 20 28 31 38 25 29 2e 20 |llaneous| (18%). |
|00004e60| 20 50 72 65 73 63 72 69 | 70 74 69 6f 6e 73 20 6e | Prescri|ptions n|
|00004e70| 6f 74 20 66 69 6c 6c 65 | 64 20 77 65 72 65 20 66 |ot fille|d were f|
|00004e80| 6f 72 20 61 6e 61 6c 67 | 65 73 69 63 73 20 6f 72 |or analg|esics or|
|00004e90| 20 6d 75 73 63 6c 65 0d | 0a 72 65 6c 61 78 61 6e | muscle.|.relaxan|
|00004ea0| 74 73 20 28 34 35 25 29 | 2c 20 61 6e 74 69 62 69 |ts (45%)|, antibi|
|00004eb0| 6f 74 69 63 73 20 28 34 | 31 25 29 20 61 6e 64 20 |otics (4|1%) and |
|00004ec0| 6d 69 73 63 65 6c 6c 61 | 6e 65 6f 75 73 20 6d 65 |miscella|neous me|
|00004ed0| 64 69 63 61 74 69 6f 6e | 73 20 28 31 34 25 29 2e |dication|s (14%).|
|00004ee0| 0d 0a 20 20 20 20 20 41 | 70 70 61 72 65 6e 74 6c |..     A|pparentl|
|00004ef0| 79 2c 20 61 62 6f 75 74 | 20 6f 6e 65 20 66 69 66 |y, about| one fif|
|00004f00| 74 68 20 6f 66 20 61 6c | 6c 20 70 72 65 73 63 72 |th of al|l prescr|
|00004f10| 69 70 74 69 6f 6e 73 20 | 69 73 73 75 65 64 20 62 |iptions |issued b|
|00004f20| 79 20 74 68 65 20 65 6d | 65 72 67 65 6e 63 79 0d |y the em|ergency.|
|00004f30| 0a 64 65 70 61 72 74 6d | 65 6e 74 20 70 68 79 73 |.departm|ent phys|
|00004f40| 69 63 69 61 6e 20 61 72 | 65 20 6e 6f 74 20 66 69 |ician ar|e not fi|
|00004f50| 6c 6c 65 64 2e 0d 0a 0d | 0a 50 6f 73 74 2d 43 6f |lled....|.Post-Co|
|00004f60| 6d 6d 65 6e 74 0d 0a 0d | 0a 20 20 20 20 20 47 65 |mment...|.     Ge|
|00004f70| 74 74 69 6e 67 20 61 20 | 70 72 65 73 63 72 69 70 |tting a |prescrip|
|00004f80| 74 69 6f 6e 20 66 72 6f | 6d 20 61 20 73 74 72 61 |tion fro|m a stra|
|00004f90| 6e 67 65 20 65 6d 65 72 | 67 65 6e 63 79 20 72 6f |nge emer|gency ro|
|00004fa0| 6f 6d 20 70 68 79 73 69 | 63 69 61 6e 20 69 73 20 |om physi|cian is |
|00004fb0| 6e 6f 74 20 74 68 65 0d | 0a 73 61 6d 65 20 61 73 |not the.|.same as|
|00004fc0| 20 67 65 74 74 69 6e 67 | 20 6f 6e 65 20 66 72 6f | getting| one fro|
|00004fd0| 6d 20 79 6f 75 72 20 75 | 73 75 61 6c 20 6d 65 64 |m your u|sual med|
|00004fe0| 69 63 61 6c 20 63 61 72 | 65 20 64 69 73 70 65 6e |ical car|e dispen|
|00004ff0| 73 65 72 2c 20 77 68 69 | 63 68 20 6d 61 79 20 65 |ser, whi|ch may e|
|00005000| 78 70 6c 61 69 6e 0d 0a | 77 68 79 20 74 68 65 20 |xplain..|why the |
|00005010| 66 69 67 75 72 65 20 6f | 66 20 32 30 25 20 72 65 |figure o|f 20% re|
|00005020| 70 6f 72 74 65 64 20 68 | 65 72 65 20 69 73 20 73 |ported h|ere is s|
|00005030| 6f 20 6d 75 63 68 20 68 | 69 67 68 65 72 20 74 68 |o much h|igher th|
|00005040| 61 6e 20 74 68 65 20 32 | 25 20 74 6f 20 35 25 0d |an the 2|% to 5%.|
|00005050| 0a 6e 6f 6e 63 6f 6d 70 | 6c 69 61 6e 63 65 20 72 |.noncomp|liance r|
|00005060| 61 74 65 20 72 65 70 6f | 72 74 65 64 20 62 79 20 |ate repo|rted by |
|00005070| 6f 74 68 65 72 73 2e 20 | 20 4f 6e 20 74 68 65 20 |others. | On the |
|00005080| 6f 74 68 65 72 20 68 61 | 6e 64 2c 20 52 61 73 68 |other ha|nd, Rash|
|00005090| 69 64 20 28 42 72 20 4d | 65 64 20 4a 0d 0a 32 38 |id (Br M|ed J..28|
|000050a0| 34 3a 32 33 2d 32 36 2c | 20 31 39 38 32 29 20 66 |4:23-26,| 1982) f|
|000050b0| 6f 75 6e 64 20 74 68 61 | 74 20 61 62 6f 75 74 20 |ound tha|t about |
|000050c0| 32 30 25 20 6f 66 20 61 | 20 63 6c 69 6e 69 63 20 |20% of a| clinic |
|000050d0| 70 6f 70 75 6c 61 74 69 | 6f 6e 20 66 61 69 6c 65 |populati|on faile|
|000050e0| 64 20 74 6f 20 66 69 6c | 6c 0d 0a 70 72 65 73 63 |d to fil|l..presc|
|000050f0| 72 69 70 74 69 6f 6e 73 | 2e 20 20 54 68 65 20 6c |riptions|.  The l|
|00005100| 65 73 73 6f 6e 3a 20 20 | 44 6f 6e 27 74 20 61 73 |esson:  |Don't as|
|00005110| 73 75 6d 65 20 79 6f 75 | 72 20 70 61 74 69 65 6e |sume you|r patien|
|00005120| 74 73 20 74 61 6b 65 20 | 74 68 65 20 6d 65 64 69 |ts take |the medi|
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|00005f00| 20 43 68 69 6c 64 7d 0d | 0a 24 56 6f 6c 75 6d 65 | Child}.|.$Volume|
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|00005f40| 31 39 38 39 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1989 Yea|r Book o|
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|00005fa0| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 4c 2e |.$Commen|tator{L.|
|00005fb0| 45 2e 20 48 6f 6c 6c 69 | 73 74 65 72 2c 20 4d 2e |E. Holli|ster, M.|
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|00005fd0| 20 28 63 29 20 59 65 61 | 72 20 42 6f 6f 6b 20 4d | (c) Yea|r Book M|
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|00006000| 0a 31 39 38 39 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1989 Ye|ar Book |
|00006010| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 20 |of Drug |Therapy |
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|00006060| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006070| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006080| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006090| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 50 72 65 73 63 |--------|-..Presc|
|000060a0| 72 69 70 74 69 6f 6e 20 | 4d 65 64 69 63 61 74 69 |ription |Medicati|
|000060b0| 6f 6e 73 20 69 6e 20 49 | 6e 66 61 6e 63 79 20 61 |ons in I|nfancy a|
|000060c0| 6e 64 20 45 61 72 6c 79 | 20 43 68 69 6c 64 68 6f |nd Early| Childho|
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|000060e0| 50 2c 20 57 69 6c 73 6f | 6e 20 4d 2c 20 44 65 41 |P, Wilso|n M, DeA|
|000060f0| 6e 67 65 6c 69 73 20 43 | 0d 0a 28 4a 6f 68 6e 73 |ngelis C|..(Johns|
|00006100| 20 48 6f 70 6b 69 6e 73 | 20 55 6e 69 76 29 0d 0a | Hopkins| Univ)..|
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|00006120| 34 31 3a 37 37 32 2d 37 | 37 35 2c 20 4a 75 6c 79 |41:772-7|75, July|
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|00006160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006170| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006180| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 0d 0a 41 62 73 74 72 |-------.|...Abstr|
|00006190| 61 63 74 0d 0a 0d 0a 20 | 20 20 20 20 42 65 63 61 |act.... |    Beca|
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+--------+-------------------------+-------------------------+--------+--------+